Genocea Biosciences (NASDAQ:GNCA) and Orchard Therapeutics (NASDAQ:ORTX) are both small-cap medical companies, but which is the better business? We will compare the two companies based on the strength of their institutional ownership, analyst recommendations, profitability, risk, valuation, dividends and earnings.

Analyst Ratings

This is a breakdown of recent ratings for Genocea Biosciences and Orchard Therapeutics, as provided by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Genocea Biosciences 0 0 2 0 3.00
Orchard Therapeutics 0 0 4 0 3.00

Genocea Biosciences presently has a consensus price target of $5.75, indicating a potential upside of 63.82%. Orchard Therapeutics has a consensus price target of $24.50, indicating a potential upside of 83.38%. Given Orchard Therapeutics’ higher probable upside, analysts plainly believe Orchard Therapeutics is more favorable than Genocea Biosciences.

Valuation and Earnings

This table compares Genocea Biosciences and Orchard Therapeutics’ top-line revenue, earnings per share (EPS) and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Genocea Biosciences $230,000.00 214.42 -$27.81 million ($3.68) -0.95
Orchard Therapeutics $2.08 million 551.52 -$230.49 million ($10.22) -1.31

Genocea Biosciences has higher earnings, but lower revenue than Orchard Therapeutics. Orchard Therapeutics is trading at a lower price-to-earnings ratio than Genocea Biosciences, indicating that it is currently the more affordable of the two stocks.


This table compares Genocea Biosciences and Orchard Therapeutics’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Genocea Biosciences N/A -468.08% -93.56%
Orchard Therapeutics N/A N/A N/A

Institutional & Insider Ownership

57.0% of Orchard Therapeutics shares are owned by institutional investors. 2.3% of Genocea Biosciences shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.


Orchard Therapeutics beats Genocea Biosciences on 7 of the 11 factors compared between the two stocks.

Genocea Biosciences Company Profile

Genocea Biosciences, Inc., a biopharmaceutical company, discovers and develops novel cancer vaccines. The company uses its proprietary discovery platform, ATLAS, to recall a patient's pre-existing CD4+ and CD8+ T cell immune responses to tumor to identify antigens for inclusion in vaccines that are designed to act through T cell (or cellular) immune responses. Its lead immuno-oncology program is GEN-009, an adjuvanted neoantigen peptide vaccine candidate, which is in preclinical stage, designed to direct a patient's immune system to attack tumor. The company is also seeking partners to develop cancer vaccines targeting tumor-associated antigens and a vaccine targeting cancers caused by Epstein-Barr virus. Genocea Biosciences, Inc. was founded in 2006 and is headquartered in Cambridge, Massachusetts.

Orchard Therapeutics Company Profile

Orchard Therapeutics plc, integrated biopharmaceutical company, develops gene therapies for serious and life-threatening rare diseases. The company's gene therapy approach seeks to transform a patient's hematopoietic stem cells into a gene-modified drug product to treat the patient's disease through a single administration. Its commercial stage products include Strimvelis, a gammaretroviral-based product for the treatment of adenosine deaminase-severe combined immunodeficiency (ADA-SCID). The company's clinical development products comprise OTL-101 for the treatment of ADA-SCID; OTL-200 to treat metachromatic leukodystrophy; OTL-103 for the treatment of Wiskott-Aldrich syndrome; OTL-102 for X-linked chronic granulomatous disease; and OTL-300 for transfusion-dependent beta-thalassemia. Its preclinical programs include OTL-201 for mucopolysaccharidosis type IIIA and OTL-202 for mucopolysaccharidosis type IIIB. The company was formerly known as Orchard Rx Ltd. Orchard Therapeutics plc was founded in 2015 and is headquartered in London, the United Kingdom.

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